Stem Cell Research

Spontaneous calcium events affect stem cell differentiation

Published in Stem Cell Week, March 3rd, 2003

"Neural stem cells can generate in vitro progenitors of the three main cell lineages found in the CNS," according to a recent study from the United Kingdom.

However, "the signaling pathways underlying the acquisition of differentiated phenotypes in these cells are poorly understood," explained F. Ciccolini and collegues, Babraham Institute.

The researchers "tested the hypothesis that Ca2+ signaling controls differentiation of neural precursors," and found "low-frequency global and local Ca2+ transients occurring predominantly during early stages of differentiation."

"Spontaneous Ca2+ signals in individual precursors were not...

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Source: Stem Cell Week (2003-03-03)

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