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Stem-Cell Research

PE-CAM-1 and SSEA-1 embryonic stem cells differentiate into epiblast cells

Published in Stem Cell Week, June 28th, 2004

PE-CAM-1 and SSEA-1 embryonic stem cells differentiate into epiblast cells.

According to recent research published in the journal Biology of Reproduction, "We examined the expression of cell-surface markers on sub-populations of mouse embryonic stem (ES) cells to identify those that were associated with cells that had the highest pluripotency."

"Flow cytometry analysis revealed a wide variation in the expression of platelet endothelial cell adhesion molecule I (PE-CAM-1) and stage-specific embryonic antigen (SSEA)-l in ES cells. Almost all SSEA-1+ cells expressed a high level of PECAM-1, and reversible repopulation was observed...

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