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Neurogenesis
Cortical neurogenesis timing is encoded within lineages of individual progenitor cells
August 14th, 2006
The timing of cortical neurogenesis is encoded within lineages of individual progenitor cells. According to recent research from the United States, "In the developing cerebral cortex, neurons are born on a predictable schedule. Here we show in mice that the essential timing mechanism is programmed within individual progenitor cells, and its expression depends solely on cell-intrinsic and environmental factors generated within the clonal lineage." "Multipotent progenitor cells undergo repeated asymmetric divisions, sequentially generating neurons in their normal in vivo order: first preplate cells, including Cajal-Retzius neurons, then deep and...
Source: Stem Cell Week (2006-08-14)
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