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Parkinson Disease

Activation of p53 signaling initiates apoptotic death in Parkinson disease

According to recent research published in the journal Apoptosis, "Mitochondrial dysfunction caused by oxidative stress and genetic defects have been implicated in the loss of dopaminergic neurons in Parkinson's disease. However, the key molecular events that provoke neurodegeneration still remain poorly understood."

"We recently showed that shortly after exposure to oxidative stress," V.D. Nair and colleagues at Mount Sinai School of Medicine in New York wrote, "only those cells showing phosphorylation of p53 at Ser-15 subsequently undergo active cell death.

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