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Stem Cell Research
5T4 antigen transiently upregulated during early embryonic stem cell differentiation
August 14th, 2006
The cell surface 5T4 antigen is transiently upregulated during early embryonic stem cell differentiation. "The 5T4 oncofetal antigen is a cell surface glycoprotein that is transiently expressed during mouse ES cell differentiation and correlates with decreased pluripotency of such cells. "We show that 5T4 antigen is transiently unregulated during HES4 and H1 human ES cell differentiation and its expression correlates with loss of the pluripotent markers OCT-4 and Tra-1-60 and upregulation of transcript markers associated with the three primary germ layers," investigators in England report. According to C.M. Ward and colleagues at...
Source: Stem Cell Week (2006-08-14)
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