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Stem Cell Research
Bone marrow stem cells prevent remodeling of ischemic heart via paracrine signaling
August 14th, 2006
Bone marrow stem cells prevent left ventricular remodeling of ischemic heart via paracrine signaling. According to a recent report published in the journal Circulation Research, "In this study, we hypothesized that bone marrow stem cells (BMSCs) protect ischemic myocardium through paracrine effects that can be further augmented with preconditioning. In in vitro experiments, cell survival factors such as Akt and eNOS were significantly increased in BMSCs following anoxia." "In the second series of experiments following coronary ligation in mice, left ventricles were randomly injected with the following: DMEM (G-1), BMSCs (G-2), and...
Source: Stem Cell Week (2006-08-14)
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