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Stem Cell Research
Stem cells suppress lymphocyte proliferation in vitro, do not prevent graft-versus-host disease
August 14th, 2006
Bone marrow mesenchymal stem cells suppress lymphocyte proliferation in vitro, but fail to prevent graft-versus-host disease in mice. According to recent research from France, "Several reports have suggested that mesenchymal stem cells (MSCs) could exert a potent immunosuppressive effect in vitro, and thus may have a therapeutic potential for T cell-dependent pathologies. We aimed to establish whether MSCs could be used to control graft-vs-host disease (GVHD), a major cause of morbidity and mortality after allogeneic hemopoietic stem cell transplantation." "From C57BL/6 and BALB/c mouse bone marrow cells, we purified and expanded MSCs characterized...
Source: Stem Cell Week (2006-08-14)
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