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Stem Cell Transplantation
Refractory cytomegalovirus infection successfully treated after stem cell transplant
August 14th, 2006
Foscarnet plus leflunomide successfully treats refractory cytomegalovirus infection following stem cell transplantation. According to a recent report from Germany, "Treatment of cytomegalovirus (CMV) disease after allogeneic hematopoietic stem cell transplantation (HSCT) is limited by toxicities of current antiviral drugs and the occurrence of drug resistant strains. "Leflunomide, an immunosuppressive agent used for treatment of rheumatoid arthritis, also has activity against CMV by impairing viral assembly. Here we report the control of refractory CMV disease by the combined use of foscarnet and leflunomide." "A 1 1/2-year-old...
Source: Stem Cell Week (2006-08-14)
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