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Tissue Engineering
Mesenchymal stem cell adhesion to PLGA scaffolds via type-I collagen fosters osteogenesis
August 14th, 2006
Initial mesenchymal stem cell adhesion to PLGA scaffolds via type-I collagen fosters osteogenesis. "The osteogenic potential of mesenchymal stem cells (MSCs) cultured on poly(lactide-co-glycolide) (PLGA) or poly(caprolactone) (PCL), two widely used polymeric biomaterials that have been reported to differentially support osteogenic differentiation, was compared in these studies. "Here we report that MSCs cultured in 3-D PLGA scaffolds for up to 5 weeks significantly upregulate osteocalcin gene expression levels. By contrast, osteocalcin expression was markedly downregulated in 3-D PCL-based constructs over the same time course," scientists in the...
Source: Stem Cell Week (2006-08-14)
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