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Artificial Liver
Solution preserves urea cycle enzymes in hepatocytes
August 14th, 2006
University of Wisconsin solution preserves urea cycle enzymes in hepatocytes. According to recent research from Argentina, "Urea cycle (UC) is the main pathway of ammonium removal. A deficiency in any of the five classical enzymes of the pathway causes a urea cycle disorder. Hepatocellular transplantation is one of the techniques applicable to treat this disorder. "In the present work, we investigated the activities and the relative expression levels of two of the UC enzymes: Carbamyl phosphate synthetase I (CPSI) and ornithine transcarbamylase (OTC), in isolated hepatocytes preserved up to 120 hours in University of Wisconsin (UW) solution at 0...
Source: Stem Cell Week (2006-08-14)
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