Stem Cell Research

Study results from N. Gassanov and colleagues update understanding of stem cell research

Published in Stem Cell Week, April 14th, 2008

"The hypothalamic post-translational processing of oxytocin (OT)-neurophysin precursor involves the formation of C-terminally extended OT forms (OT-X) that serve as intermediate prohormones. Despite abundant expression of the entire functional OT system in the developing heart, the biosynthesis and implication of OT prohormones in cardiomyogenesis remain unknown," investigators in Montreal, Canada report.

"In the present work, we investigated the involvement of OT-X in cardiac differentiation of embryonic stem (ES) cells. Functional studies revealed the OT receptor-mediated cardiomyogenic action of OT-Gly-Lys-Arg (OT-GKR). To obtain further insight into the mechanisms...

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Source: Stem Cell Week (2008-04-14)

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