Stem Cell Week
Welcome to NewsRx!
Learn more about a six-week, no-risk free trial of Stem Cell Week
We're a pay-per-view site for premium content. If you'd like to purchase this article, it's only $3.00.
Gene Therapy
Studies from Columbus Children's Hospital in the area of gene therapy described
August 25th, 2008
"Fanconi anemia ( FA) is a rare recessive syndrome, characterized by congenital anomalies, bone marrow failure, and predisposition to cancer. Two earlier clinical trials utilizing gamma-retroviral vectors for the transduction of autologous FA hematopoietic stem cells ( HSCs) required extensive in vitro manipulation and failed to achieve detectable long-term engraftment of transduced HSCs," scientists in the United States report. "As a strategy for minimizing ex vivo manipulation, we investigated the use of a ''rapid'' lentiviral transduction protocol in a murine Fanca(-/-) model. Importantly, while this and most murine models of FA fail to completely mimic the human...
Source: Stem Cell Week (2008-08-25)
|
