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Hematopoiesis
New findings reported from University of Tokyo, Medical Department describe advances in hematopoiesis
August 25th, 2008
According to recent research published in the journal Cancer Science, "Evi-1 is a zinc-finger transcriptional factor whose inappropriate expression leads to leukemic transformation in mice and humans. Recently, it has been shown that Evi-1 regulates proliferation of hematopoietic stem/progenitor cells at embryonic stage via GATA-2 up-regulation; however, detailed mechanisms underlying Evi-1-mediated early hematopoiesis are not fully understood." "We therefore evaluated hematopoietic potential of Evi-1 mutants using a cultivation system of murine para-aortic splanchnopleural (P-Sp) regions, and found that both the first zinc finger domain and the acidic domain...
Source: Stem Cell Week (2008-08-25)
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