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Neurogenetic
Study results from University of Cambridge broaden understanding of neurogenetic
August 25th, 2008
According to a study from Cambridge, the United Kingdom, "Flattening the diurnal corticosterone rhythm prevented the stimulating action of L-NAME (a nitric oxide synthase, NOS, inhibitor) on progenitor cell proliferation in the dentate gyrus in Lister-Hooded adult male rats. The increased expression of brain-derived neurotrophic factor (BDNF) and trkB mRNA in the dentate gyrus which otherwise occurred after L-NAME was also prevented by clamping the corticoid rhythm in adrenalectomized rats, but was restored by daily additional injections of corticosterone (which replicates the diurnal rhythm)." "Unilateral infusions of BDNF into the lateral ventricle increased...
Source: Stem Cell Week (2008-08-25)
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