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RNA Research
New RNA research study results from Columbia University described
August 25th, 2008
According to recent research from the United States, "Development of the nervous system requires that timely withdrawal from the cell cycle be coupled with initiation of differentiation. Ubiquitin-mediated degradation of the N-Myc oncoprotein in neural stem/ progenitor cells is thought to trigger the arrest of proliferation and begin differentiation." "Here we report that the HECT-domain ubiquitin ligase Huwe1 ubiquitinates the N-Myc oncoprotein through Lys 48-mediated linkages and targets it for destruction by the proteasome. This process is physiologically implemented by embryonic stem (ES) cells differentiating along the neuronal lineage and in the mouse brain during...
Source: Stem Cell Week (2008-08-25)
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