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Stem Cell Research
Findings from N. Li et al in stem cell research reported
August 25th, 2008
According to recent research from the United States, "TP63 is required for preservation of epithelial regenerative stasis and regulates the activity of diverse genetic pathways; however, specific effector pathways are poorly understood. Data presented here indicate that reciprocal regulatory interactions between hedgehog signaling and TP63 mediate stage-specific effects on proliferation and clonigenicity of separable enriched mammary stem and progenitor fractions." "Analysis of Delta N-p63 and TA-p63 indicates segregated expression in mammary stem and progenitor fractions, respectively, demonstrating that differential TP63 promoter selection occurs during elaboration of...
Source: Stem Cell Week (2008-08-25)
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