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Stem Cell Research
New findings from University of Alberta describe advances in stem cell research
August 25th, 2008
"Carboxypeptidase M (CPM) is a membrane-bound zinc-dependent protease that cleaves C-terminal basic residues, such as arginine or lysine, from peptides/proteins. We examined whether CPM is expressed by hematopoietic and stromal cells and could degrade stromal cell-derived factor (SDF)-1 alpha, a potent chemoattractant for hematopoietic stem/progenitor cells (HSPC)," scientists writing in the journal Stem Cells report. "We found that (a) CPM transcript is expressed by bone marrow (BM) and mobilized peripheral blood CD34(+) cells, myeloid, erythroid, and megakaryocytic cell progenitors, mononuclear cells (MNC), polymorphonuclear cells (PMN), and stromal cells,...
Source: Stem Cell Week (2008-08-25)
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