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Gene Therapy
Studies from T. Moreau et al provide new data on gene therapy
August 25th, 2008
According to recent research published in the journal Gene Therapy, "Further development of haematopoietic stem cell (HSC) gene therapy will depend on enhancement of gene transfer safety: ad hoc improvement of vector design relating to each particular disease is thus a crucial issue for HSC gene therapy. We modified a previously described lentiviral vector by adding the E mu mar B-specific enhancer to a human CD19 promoter-derived sequence (Mol Ther 2004; 10: 45-56)." "We thus significantly improved the level of expression of the green fluorescent protein (GFP) reporter gene while retaining the specificity of expression in B-cell progeny of transduced human CD34+...
Source: Stem Cell Week (2008-08-25)
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