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Fusion Proteins
New findings reported from J. Chen and co-authors describe advances in fusion proteins
September 15th, 2008
According to recent research from the United States, "Reciprocal chromosomal translocations at the MLL gene locus result in expression of novel fusion proteins, such as MLL-ENL, associated with leukemia. The three PHD finger cassette, one of the highly conserved domains in AILL, is absent in all fusion proteins." "This domain has been shown to interact with Cyp33, a cyclophilin which enhances the recruitment of histone deacetylases (HDAC) to the NILL repression domain and mediates HOX gene repression. Insertion of the third PHD finger of MLL into MLL-ENL allows the recruitment of Cyp33 and, subsequently, HDACI to the fusion protein. Furthermore, expression of the fusion...
Source: Stem Cell Week (2008-09-15)
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