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University of Rochester Medical Center

Gene find sheds light on motor neuron diseases like ALS

Published in Stem Cell Week, November 3rd, 2008

Scientists have identified a gene in mice that plays a central role in the proper development of one of the nerve cells that goes bad in amyotrophic lateral sclerosis, or Lou Gehrig's disease, and some other diseases that affect our motor neurons.

The study is the result of a collaboration by scientists at the University of Rochester Medical Center who normally focus on the eye, working together with a developmental neuroscientist at Harvard who focuses on the cerebral cortex. The work appears in the Oct. 23 issue of the journal Neuron.

The work centers on corticospinal neurons, crucial nerve cells that connect the brain to the spinal cord. These...

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