Stem Cell Research

Research data from Nanjing Medical University update understanding of stem cell research

Published in Stem Cell Week, November 10th, 2008

"Neural cells undergo glutamate-induced apoptosis in ischaemic brain tissue, in which prostate apoptosis response-4 gene (Par-4) is involved. Human-bone mesenchymal stem cells can be utilized as an effective therapy for ischemic brain injury," scientists writing in the journal Nucleic Acids Research report.

"In this study, we found that glutamate could induce apoptosis in human-bone mesenchymal stem cells, accompanied by increased expression of Par-4 gene and Smac release from mitochondria. Repressing Par-4 expression attenuated the glutamate-induced apoptosis. Both Par-4 protein and E2F1 protein could bind to E2F1-binding BS3 site on Smac promoter and...

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Source: Stem Cell Week (2008-11-10)

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