Gene Therapy
Reports on gene therapy findings from University of Modena provide new insights
Published in Stem Cell Week, December 22nd, 2008
According to a study from Modena, Italy, "Although a considerable number of reports indicate an involvement of the Hox-A10 gene in the molecular control of hemopoiesis, the conclusions of such studies are quite controversial given that they support, in some cases, a role in the stimulation of stem cell self-renewal and myeloid progenitor expansion, whereas in others they implicate this transcription factor in the induction of monocyte-macrophage differentiation. To clarify this issue, we analyzed the biological effects and the transcriptome changes determined in human primary CD34(+) hemopoietic progenitors by retroviral transduction of a full-length Hox-A10 cDNA."
"The...
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Source: Stem Cell Week (2008-12-22)
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