Stem Cell Research

Studies from University of Virginia in the area of stem cell research described

Published in Stem Cell Week, December 22nd, 2008

According to recent research published in the journal Cell, "Chromatin undergoes developmentally-regulated structural and chemical changes as cells differentiate, which subsequently lead to differences in cellular function by altering patterns of gene expression. To gain insight into chromatin alterations that occur during mammalian differentiation, we turned to a mouse embryonic stem cell (ESC) model."

"Here we show that histone H3 is proteolytically cleaved at its N-terminus during ESC differentiation. We map the sites of H3 cleavage and identify Cathepsin L as a protease responsible for proteolytically processing the N-terminal H3 tail. In addition, our data...

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Source: Stem Cell Week (2008-12-22)

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