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Colitis
Research from University of Alabama yields new findings on colitis
June 15th, 2009
"P-glycoprotein (P-gp), the product of the multidrug resistance gene (MDR), is an ATP-dependent transmembrane pump. which is expressed in multiple cell lineages including epithelial and hematopoetic cells. The human MDR gene is located on chromosome 7 (7q21.1), a susceptibility loci for inflammatory bowel disease (IBD)," scientists writing in the journal Inflammatory Bowel Diseases report. "A significant number of IBD patients carry mutations in this gene and P-gp-deficient FVB/N mice develop a severe spontaneous colitis. characterized by impaired intestinal barrier function and immune reactivity to intestinal bacterial antigens. In this work we explored the role...
Source: Stem Cell Week (2009-06-15)
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