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Heart Attack
Findings from University of Munich advance knowledge in heart attack
June 15th, 2009
"Ischemic cardiomyopathy is one of the main causes of death, which may be prevented by stem cell-based therapies. SDF-1 alpha is the major chemokine attracting stem cells to the heart," scientists in Munich, Germany report. "Since SDF-1 alpha is cleaved and inactivated by CD26/dipeptidylpeptidase IV (DPP-IV), we established a therapeutic conceptapplicable to ischemic disorders in general-by combining genetic and pharmacologic inhibition of DPP-IV with G-CSF-mediated stem cell mobilization after myocardial infarction in mice. This approach leads to (1) decreased myocardial DPP-IV activity, (2) increased myocardial homing of circulating CXCR-4(+) stem cells, (3) reduced...
Source: Stem Cell Week (2009-06-15)
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