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Cyclooxygenase
Findings from University of Washington advance knowledge in cyclooxygenase
July 13th, 2009
According to recent research from the United States, "Prostaglandin E-2 is one of several eicosanoid products of the cyclooxygenase isozymes and is a key regulator of innate immune responses; it also possesses paracrine effects on mature neurons. The prostaglandin E, receptor family consists of four subtypes of which EP1 and EP2 are known to be expressed by microglia." "Lipopolysaccharide (LPS)-induced innate immune activation leads to the degeneration of intermediate progenitor cells (IPCs) that are destined for neuronal maturation in the hippocampal subgranular zone (SGZ); these cells can be identified by the expression of the transcription factor T-box brain gene 2...
Source: Stem Cell Week (2009-07-13)
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