Neurodegenerative Disease
University of Wisconsin details research in neurodegenerative disease
Published in Stem Cell Week, October 19th, 2009
"The amyloid-beta precursor protein (A beta PP) is a ubiquitously expressed transmembrane protein whose cleavage product, the amyloid-beta(A beta) protein, is deposited in amyloid plaques in neurodegenerative conditions such as Alzheimer disease, Down syndrome, and head injury. We recently reported that this protein, normally associated with neurodegenerative conditions, is expressed by human embryonic stem cells (hESCs)," scientists in the United States report.
"We now report that the differential processing of A beta PP via secretase enzymes regulates the proliferation and differentiation of hESCs. hESCs endogenously produce amyloid-beta, which when added exogenously...
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Source: Stem Cell Week (2009-10-19)
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