Stem Cell Research

Data on stem cell research described by E.A. Kruse et al

Published in Stem Cell Week, October 19th, 2009

"Fli-1 and Erg are closely related members of the Ets family of transcription factors. Both genes are translocated in human cancers, including Ewing's sarcoma, leukemia, and in the case of Erg, more than half of all prostate cancers," scientists in Parkville, Australia report.

"Although evidence from mice and humans suggests that Fli-1 is required for megakaryopoiesis, and that Erg is required for normal adult hematopoietic stem cell (HSC) regulation, their precise physiological roles remain to be defined. To elucidate the relationship between Fli-1 and Erg in hematopoiesis, we conducted an analysis of mice carrying mutations in both genes. Our results demonstrate that...

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Source: Stem Cell Week (2009-10-19)

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