Transfusion Medicine

New research on transfusion medicine from G. Migliaccio and co-authors summarized

Published in Stem Cell Week, January 25th, 2010

"Cultured human erythroid cells derived in vitro may represent alternative transfusion products. It is unknown, however, if these ex vivo expanded erythroid cells remain functional or develop genetic abnormalities after storage," investigators in the United States report.

"Using mononuclear cells from four adult blood donors, erythroblasts were generated ex vivo in expansion cultures supplemented with stem cell factor, interleukin-3, erythropoietin (EPO), dexamethasone, and estradiol. The viability and in vitro function of freshly expanded or short (1-2 months)-and long (8 years)-term-stored erythroblasts cryopreserved in dimethyl sulfoxide were compared. Erythroblast...

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Source: Stem Cell Week (2010-01-25)

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