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Ohio State University, U.S.

Failure of immune system scout cells may lead to cancer in transplant patients

Published in Surgery Litigation and Law Weekly, September 1st, 2006

A serious form of cancer that occurs in some transplant patients may arise because cells that normally serve as scouts for the immune system become weakened, a new study led by Ohio State University scientists suggests.

The cancer, called post-transplant lymphoproliferative disorder (PTLD), is caused by Epstein-Barr virus (EBV), a herpes virus that infects more than 90% of Americans but is ordinarily kept under control by the immune system. That control can be lost in people whose immune system is suppressed to prevent rejection of a transplanted organ. The cancer arises only in some transplant patients, but doctors don't know why.

Study findings are...

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