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Institute for Clinical & Experimental Medicine, Czech Republic

Cardiac surgery lactate levels are not influenced by IL-10 and TNF-beta gene polymorphisms

Published in Surgery Litigation and Law Weekly, September 8th, 2006

IL-10 and TNF-beta gene polymorphisms have no major influence on lactate levels after cardiac surgery.

"Lactate levels after cardiac surgery are influenced by different proinflammatory (TNF, IL-6, IL-8) and anti-inflammatory (IL-10) cytokines. The goal of the study was to determine the relationship between polymorphism in the IL-10 (-1082G/A) and TNF-beta (+252G/A) genes and lactate levels in patients after cardiac surgery. We performed a prospective observational study in 168 consecutive adult patients without left ventricle dysfunction undergoing elective coronary artery bypass grafting," investigators in the Czech Republic report.

"Lactic acid...

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