Pathology
Researchers at Children's Hospital, Department of Pathology target pathology
Published in Surgery Litigation and Law Weekly, July 13th, 2007
A new study, "Novel karyotypes in giant cell-rich lesions of bone," is now available. "Giant cell-rich lesions of bone, including giant cell tumor of bone, giant cell reparative granuloma (GCRG), and aneurysmal bone cyst (ABC), may have overlapping clinical, radiologic, and histopathologic features. In fact, GCRG and solid ABC are currently differentiated solely based on skeletal location," investigators in the United States report.
"Prior cytogenetic studies have reported that telomeric associations are present in the majority of giant cell tumors of bone, whereas translocations involving 16q22 and/or 17p13 are characteristic of ABCs. There is only one previously...
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