Ischemia

Research findings from P. Cascalessanchez et al update understanding of ischemia

Published in Surgery Litigation and Law Weekly, December 14th, 2007

According to a study from Albacete, Spain, "Cytoprotective effects on the liver of somatostatine (ST) and octreotide (OT) have been previously described in normothermic ischemia-reperfusion models. The purpose of this study was an enzymatic and morphological assessment of hepatic cytoprotective effects during extended cold storage."

"Rat livers were washed in situ via the portal vein with University of Wisconsin solution (UW) UW+ST, or UW+OT. After 24 or 48 hours of cold ischemia time (CIT), livers were reperfused for 2 hours via the portal vein with oxygenated KHB at 37 degrees C using a nonrecirculating ex situ isolated perfusion system. Levels of aspartate...

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Source: Surgery Litigation and Law Weekly (2007-12-14)

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