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Salmonellosis

Studies from University of Stockholm in the area of salmonellosis described

Published in Surgery Litigation and Law Weekly, May 9th, 2008

"The tailspike protein P22 recognizes an octasaccharide derived from the O-antigen polysaccharide of Salmonella enteritidis in a shallow groove and molecular docking successfully identifies this binding region on the protein surface," investigators in Stockholm, Sweden report.

"Analysis by 2D H-1, H-1-T-ROESY and transferred NOESY NMR experiments indicate that the bound octasaccharide ligand has a conformation similar to that observed in solution. The results from a saturation transfer difference NMR experiment show that a large number of protons in the octasaccharide are in close contact with the protein as a result of binding," wrote J. Landstroem and colleagues,...

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