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Diabetic Nephropathy

Data on diabetic nephropathy described by researchers at St. Vincent's Hospital

Published in Surgery Litigation and Law Weekly, May 16th, 2008

According to a study from Fitzroy, Australia, "Aims/hypothesis Activation of protein kinase C (PKC) isoforms has been implicated as a central mediator in the pathogenesis of diabetic nephropathy. Although high glucose levels stimulate catalytic activity of PKC, the effects of high glucose levels on the expression of genes encoding PKC isoforms are unknown."

"We sought to determine whether in addition to activation, diabetes may lead to increased transcription of two PKC isoforms that have been implicated in the pathogenesis of diabetic nephropathy, PKC-alpha and PKC-beta. Recent advances in molecular biological techniques now permit quantitative analysis of mRNA from...

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