Ischemia Animal Studies
New findings from University of Chile, Institute of Biomedical Science in the area of ischemia animal studies described
Published in Surgery Litigation and Law Weekly, May 30th, 2008
A new study, 'Causal role of oxidative stress in liver preconditioning by thyroid hormone in rats,' is now available. "Hepatic ischemia-reperfusion (IR) injury, a major clinical drawback during surgery, is abolished by L-3,3',5-triiodothyronine (T(3)) administration. Considering that the triggering mechanisms are unknown, the aim of this study is to assess the role of oxidative stress in T(3) preconditioning using N-acetylcysteine (NAC) before T(3) administration," investigators in Santiago, Chile report.
"Male Sprague-Dawley rats given a single dose of 0.1 mg of T(3)/kg were subjected to 1 h ischemia followed by 20 h reperfusion, in groups of animals pretreated with...
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