Enzyme Research

Investigators at University of Modena target enzyme research

Published in Surgery Litigation and Law Weekly, July 11th, 2008

According to recent research from Modena, Italy, "The elucidation of the structural/functional specificities of highly conserved enzymes remains a challenging area of investigation, and enzymes involved in cellular replication ore important targets for functional studies and drug discovery. Thymidylate synthase (TS, ThyA) governs the synthesis of thymidylate for use in DNA synthesis."

"The present study focused on Lactobacillus casei TS (LcTS) and Escherichia coli TS (EcTS), which exhibit 50% sequence identity and strong folding similarity. We have successful-designed and validated a chemical model in which linear, but not constrained, dansyl derivatives specifically...

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Source: Surgery Litigation and Law Weekly (2008-07-11)

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