Published in Surgery Litigation and Law Weekly, August 15th, 2008
"Thus, inhibiting Ca2+ entry might attenuate post-traumatic lung injury. Inhibiting voltage-ope rated (L-type) Ca2+ channels during shock could cause cardiovascular collapse, but PMN are ''nonexcitable'' cells, lack L-type channels, and mobilize Ca2+ via nonspecific channels. We previously showed that PMN Ca2+ entry requires sphingosine I-phosphate synthesis by sphingosine kinase and that both sphingosine...
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