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Project A.L.S.

First disease-specific stem cells from human skin cells

Published in Surgery Litigation and Law Weekly, August 22nd, 2008

A team of researchers from the Harvard Stem Cell Institute (HSCI) and Columbia University, in a collaboration catalyzed by the Project A.L.S./Jenifer Estess Laboratory for Stem Cell Research, has demonstrated that pluripotent stem cells generated from a patient with ALS (amyotrophic lateral sclerosis) can be directed to differentiate into motor neurons—the very brain cells destroyed by ALS. The results of the team's study appear in today's online issue of Science. This is the first published report to show that disease-specific stem cells may be derived from an individual patient.

In the study, led by Kevin Eggan, of the Harvard Stem Cell Institute, skin cells taken...

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