Kidneys
Research from Tel-Aviv University in kidneys provides new insights
Published in Surgery Litigation and Law Weekly, September 26th, 2008
New research, 'Rosiglitazone improves aortic arginine transport, through inhibition of PKCalpha, in uremic rats,' is the subject of a report. According to a study from Tel Aviv, Israel, "Peroxisome proliferator-activated receptor (PPAR) agonists were shown to inhibit atherosclerosis through augmentation of endothelial nitric oxide synthase (eNOS) activity. In addition, rosiglitazone exerts a beneficial effect in chronic renal failure (CRF)."
"Since l-arginine transport by CAT-1 (the specific arginine transporter for eNOS) is inhibited in uremia, we aimed to explore the effect of rosiglitazone on arginine transport in CRF. Arginine uptake by aortic rings was studied in...
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