Antisense Technology

Findings from University of Arizona provide new insights into antisense technology

Published in Surgery Litigation and Law Weekly, November 21st, 2008

"Ischemia/reperfusion injury is a leading cause of renal damage which can be improved with antisense oligonucleotide gene therapy. We have shown that polyethylene glycol (PEG) hydrogel, which also functions as a tissue sealant, is an effective topical delivery vehicle for oligonucleotides in a murine partial nephrectomy model," investigators in the United States report.

"The objective of this study was to use and evaluate this method against intercellular adhesion molecule-1 (ICAM-1) to prevent tissue damage. Sixty mice underwent left upper pole partial nephrectomy with 45 minutes of warm ischemia, randomized to treatment with 50 mu g ICAM-1 antisense oligonucleotides...

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Source: Surgery Litigation and Law Weekly (2008-11-21)

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