Enzyme Research
Findings in enzyme research reported from E.M. Puchner and co-researchers
Published in Surgery Litigation and Law Weekly, November 28th, 2008
According to recent research published in the journal Proceedings of the National Academy of Sciences of the United States of America, "Biological responses to mechanical stress require strain-sensing molecules, whose mechanically induced conformational changes are relayed to signaling cascades mediating changes in cell and tissue properties. In vertebrate muscle, the giant elastic protein titin is involved in strain sensing via its C-terminal kinase domain (TK) at the sarcomeric M-band and contributes to the adaptation of muscle in response to changes in mechanical strain."
"TK is regulated in a unique dual autoinhibition mechanism by a C-terminal regulatory...
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