Endocrine Research
Reports outline endocrine research study findings from A.M. Schmitt and colleagues
Published in Surgery Litigation and Law Weekly, December 25th, 2009
New research, 'VHL inactivation is an important pathway for the development of malignant sporadic pancreatic endocrine tumors,' is the subject of a report. "A small subset of familial pancreatic endocrine tumors (PET) arises in patients with von Hippel-Lindau syndrome and these tumors may have an adverse outcome compared to other familial PET. Sporadic PET rarely harbors somatic VHL mutations, but the chromosomal location of the VHL gene is frequently deleted in sporadic PET," researchers in Zurich, Switzerland report.
"A subset of sporadic PET shows active hypoxia signals on mRNA and protein level. To identify the frequency of functionally relevant VHL inactivation in...
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