Angiotensins
Findings from D.J. Campbell and co-researchers advance knowledge in angiotensins
Published in Surgery Litigation and Law Weekly, January 15th, 2010
"We reported previously that targeted expression of rat prorenin to the liver under the control of the human alpha 1-antitrypsin promoter increased plasma prorenin levels by several-hundred-fold in male transgenic rats and caused cardiac hypertrophy, severe renal lesions, and myocardial fibrosis by 20 weeks of age, despite normal blood pressure. We examined the evolution of the phenotype of male transgenic rats over 12 months and the effects of binephrectomy on the renin-angiotensin (Ang) system," scientists writing in the journal Hypertension report.
"Plasma prorenin levels were > 1000-fold higher than in wild type littermates, whereas plasma and renal Ang II...
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