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Myeloma

Study results from University of Minnesota, Medical Department update understanding of myeloma

Published in Surgery Litigation and Law Weekly, February 26th, 2010

"Local recurrence with subsequent osteolysis is a problem after intralesional curettage of giant cell tumor of bone, myeloma, and metastatic carcinoma. The bisphosphonate zoledronic acid (zoledronate) has been shown to reduce osteoclast activity, and its local administration is a potentially attractive therapy, especially for the osteoclast-rich giant cell tumor," scientists writing in the Journal of Bone and Joint Surgery - American Volume report.

"The aim of this study was to analyze the elution dynamics of zoledronic acid release from acrylic bone cement and its in vitro antitumor efficacy. Various concentrations of zoledronic acid were mixed with bone cement...

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