BCG Vaccine

Impact of Strain on Efficacy Unknown

Published in TB and Outbreaks Week, February 13th, 1995

The true impact of strain on the protective efficacy of the bacille Calmette-Guerin (BCG) vaccine can not be determined until more sophisticated studies are done, according to a report from the Harvard School of Public Health.

A possible explanation for the observed variation in the efficacy of BCG vaccine in preventing tuberculosis (TB) is that different BCG strains have been used in different studies.

"We recently performed a meta-analysis of BCG vaccination in the prevention of tuberculosis to obtain a more powerful estimate of overall efficacy and to explore the reasons for the divergent results reported in numerous studies conducted so far,"...

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Source: TB and Outbreaks Week (1995-02-13)

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