Pediatrics

RFLP/PCR Useful in Study of TB Outbreaks in Children

Published in TB and Outbreaks Week, March 6th, 1995

Restriction fragment length polymorphism (RFLP) and arbitrarily primed polymerase chain reaction (PCR) analysis were found to be effective in the investigation of two outbreaks of pediatric tuberculosis (TB) in a Spanish study.

During the past three years there have been numerous outbreaks of TB caused by organisms resistant to multiple anti-TB drugs. Most outbreaks have generally involved persons infected with HIV, who are believed to have been exposed to strains in medical or correctional facilities.

Only a few reports describe outbreaks with TB transmission in children, especially in a day-care setting.

"This report describes...

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Source: TB and Outbreaks Week (1995-03-06)

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