Pathogenesis - TB
"Cloning, Overexpression and Enzymology of the DNA Polymerase I from Mycobacterium tuberculosis."
Published in TB and Outbreaks Week, April 3rd, 1995
According to an abstract presented by the authors to the Molecular Mechanisms in Tuberculosis Keystone Symposium, held February 19-25, 1995, in Tamarron, Colorado, "The polA gene encoding the DNA polymerase I (PolI) from M. tuberculosis was cloned using a probe generated by consensus sequence PCR amplification of genomic DNA (Mizrahi, V., Huberts, P., Dawes, S.S. and Dudding, L.R. (1993) Gene 136, 287-290). The G+C content of the structural gene is 67% and it encodes a polypeptide of 904 amino acids that shares 89% amino acid identity with the 911-amino acid homologue from M. leprae. The M. leprae polA gene is flanked by similar but not identical RLEP...
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