Drug Resistance
"Identification of Specific Mutations Responsible for Rifampin and Rifabutin Resistance in Mycobacterium Tuberculosis Using a Mutagenesis and Expression System of the Cloned M. Tuberculosis BEG
Published in TB and Outbreaks Week, April 10th, 1995
According to an abstract presented by the authors to the Molecular Mechanisms in Tuberculosis Keystone Symposium, held February 19-25, 1995, in Tamarron, Colorado, "To define the mechanism of rifampin resistance, we cloned and sequenced the rpoB gene of Mycobacterium tuberculosis and expressed its gene product (the 13 subunit of RNA polymerase) in M. smegmatis [L.P. Miller, J.T. Crawford, T.M. Shinnick, Antimicrob. Agents Chemother. 38, 705 (1994)]. Based on this study, we developed a method to characterize the role of a specific mutation in rifampin and rifabutin resistance in M. tuberculosis. The 5.1-kb genomic SacI fragment carrying the M....
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