"Mutation Position and Type of Substitution in the Beta-Subunit of the RNA Polymerase Influence In-Vitro Activity of Rifamycins in Rifampicin-Resistant Mycobacterium tuberculosis."

According to the authors' abstract of an article published in Journal of Antimicrobial Chemotherapy, "Quantitative susceptibility testing for rifampicin, rifabutin and rifapentine of 36 Mycobacterium tuberculosis isolates with known sequences for the gene encoding for the RNA polymerase beta-subunit (rpoB) revealed that both mutation position and type of amino acid substitution influence the in-vitro activity of rifamycins in rifampicin-resistant strains." The corresponding author for this study is: T Bodmer, Univ Bern, Inst Med Microbiol, CH-3010 Bern, Switzerland. For subscription information for this journal contact the publisher: W B Saunders Co Ltd, 24-28 Oval Rd, London,...

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